Vasculitis refers to a heterogeneous group of disorders that are characterized by inflammatory destruction of blood vessels. Both arteries and veins affected. Vasculitis is primarily due to leukocyte migration and resultant damage.
Myeloperoxidase is a lysosomal enzyme that can be found in human neutrophils. There are two subsets of autoantibodies to human neutrophils: c-ANCA and p-ANCA.